Addition Therapeutics Debuts With $100 Million

<p><strong>SOUTH SAN FRANCISCO <&sol;strong>– Addition Therapeutics has debuted from stealth with &dollar;100 million in financing to date and notable progress advancing its mission to fulfill the transformative promise of genomic medicine for people impacted by both chronic and rare diseases&period; Leveraging its breakthrough all-RNA&comma; non-viral&comma; lipid nanoparticle &lpar;LNP&rpar;-based PRINT &lpar;<strong>P<&sol;strong>recise <strong>R<&sol;strong>NA-Mediated <strong>In<&sol;strong>sertion of <strong>T<&sol;strong>ransgenes&rpar; platform&comma; Addition aims to develop safer&comma; durable&comma; one-time therapies&comma; overcoming limitations of current genetic medicine modalities&period; The company was first created inside of UC-Berkeley&period;<&sol;p>&NewLine;<p>Addition is advancing a pipeline of PRINTed therapeutics that have the potential to fundamentally redefine how chronic and rare diseases are treated&period; Initial disease-related NHP studies are planned for 2026&period; Addition’s investor syndicate includes SR One&comma; Pivotal Life Sciences&comma; Abingworth&comma; Osage University Partners&comma; the Gates Foundation&comma; and BEVC&period;<&sol;p>&NewLine;<p>&OpenCurlyDoubleQuote;Our bold vision at Addition Therapeutics is to achieve genomic medicine’s powerful&comma; long-held promise for patients and forge new frontiers for what’s possible in the treatment of disease&comma;” said Ron Park&comma; M&period;D&period;&comma; MBA&comma; Chief Executive Officer at Addition&period; &OpenCurlyDoubleQuote;Bolstered by our team of top-tier scientists and engineers and our high-caliber investors&comma; we have built a world-class technology platform and a pipeline of novel chronic and rare disease programs&period; Today&comma; we’re excited to start sharing our progress and momentum&period;”<&sol;p>&NewLine;<p>Matt Patterson&comma; Chairman of Addition’s Board of Directors and Venture Partner with SR One&comma; commented&comma; &OpenCurlyDoubleQuote;Addition brings together an extraordinary platform&comma; a highly skilled team&comma; and disciplined planning and execution&period; The external support Addition has received from this outstanding group of funders and several top pharma companies will enable the continued advancement of its patient-centric mission&period; I look forward to Addition’s progress in the years ahead&period;”<&sol;p>&NewLine;<p>Addition is a spin-out of Professor Kathleen Collins’ laboratory at University of California&comma; Berkeley&comma; where she is Professor and former Head of the Division of Biochemistry&comma; Biophysics&comma; and Structural Biology and holds the endowed Walter and Ruth Schubert Family Chair&period; The foundational technology for PRINT is based on Dr&period; Collins’ best-in-class retrotransposase expertise&comma; combined with technology development backed by entrepreneurship funding from the Bakar Fellows Program and an NIH Director’s Pioneer Award&period; Pivotal Life Sciences seeded the company as it spun out of UC Berkeley&period;<&sol;p>&NewLine;<p>&OpenCurlyDoubleQuote;While we’ve seen important progress over the last decade&comma; gene therapy modalities approaching or in the clinic are limited in their technical capabilities and restricted in their applicability and adoption&period; Harnessing retrotransposon machinery to achieve precise transgene insertion to the ideal genomic safe-harbor site is an elegant and versatile new drug mechanism&comma;” said Dr&period; Collins&period; &OpenCurlyDoubleQuote;It’s thrilling to see the Addition team’s evolution of this technology into a powerful platform and a pipeline that has the potential to help usher in a new era of genomic medicines&period;”<&sol;p>&NewLine;

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